Table 1

Identification of 31 down-regulated miRNAs from a list of 71 up-regulated mRNAs

Down-regulated miRNA

miRNA family

No. of mRNA targets

Target genes predicted by the PLS method


*hsa-let-7 g

Let-7 g

17

BUD31, COTL1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, NAP1L4, NUDT1, PHB, PSMC2, PSMC4, PUF60, Ras-Like protein, RPL10, SRD5A3, WDR36


hsa-miR-1

miR-1

1

RPL10


hsa-miR-100

miR-100

1

GSTP1


*hsa-miR-101

miR-101

7

ATP6V0B, GTF2IRD1, GUK1, NEBL, PSMB4, UBE2I, VKORC1


hsa-miR-10b

miR-10b

2

MIF, PSMC2


hsa-miR-126

miR-126

16

ANXA2, CSTB, DDIT4, GPATCH3, GTF2IRD1, GUK1, MDK, NDK, NEBL, OAZ1, PSMB4, S100A11, SLC7A11, TBCD, UBA6, VKORC1


hsa-miR-130a

miR-130

2

GSTP1, RPL34


*hsa-miR-133a

miR-133

17

ANXA2, ATP6V0B, CSTB, GPATCH3, GPX1, GTF2IRD1, NAP1L4, NEBL, OAZ1, POLR2H, PSMB4, RPL10, SLC7A11, TBCD, UBA6, UBE2I, VKORC1


hsa-miR-142-5p

miR-142

6

ARPC1B, DDIT4, GSTP1, MDK, TUFM, USP22


*hsa-miR-150

miR-150

20

ABHD12, C7orf28A, CLIC1, CPNE1, EIF3B, GSTP1, GTF3C1, IFITM1, LAPTM5, NAP1L4, ODC1, PRDX2, PSMB2, PSMC4, PSMD8, PUF60, RPL10, SRD5A3, TBCD, Wilm's tumor-related protein


*hsa-miR-15a

miR-15

8

C7orf28A, CAPG, CPNE1, GTF3C1, NUDT1, PSMD8, WDR36, Wilm's tumor-related protein


*hsa-miR-16

miR-16

8

FTL, GTF3C1, LAPTM5, PHB, PSMD8, SRD5A3, WDR36, Wilm's tumor-related protein


hsa-miR-195

miR-195

2

PSMD8, RPL10


hsa-miR-26a

miR-26

3

CAPG, FTL, GTF3C1


hsa-miR-26b

miR-26

15

ATP6V0B, BUD31, CANX, CAPG, EIF3B, FTL, MIF, NAP1L4, NUDT1, ODC1, POLR2H, PSMC2, PSMC4, UBE2I, WDR36


hsa-miR-28

miR-28

21

ABHD12, ARPC1B, CLIC1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, LAPTM5, NAP1L4, ODC1, PRDX2, PSMB2, PSMC4, PSMD8, PUF60, RPL10, RPS9, SRD5A3, TUFM, Wilm's tumor-related protein


*hsa-miR-29b

miR-29

15

ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, ITPA, MDK, PSMB4, S100A11, SLC7A11, USP22, VKORC1, ZNF37A


*hsa-miR-29c

miR-29

7

ABHD12, C7orf28A, PSMD8, RPL10, TBCD, USP22, ZNF37A


*hsa-miR-30a

miR-30

22

ANXA2, C7orf28A, CAPG, CSTB, DAP, GPATCH3, GPX1, GTF2IRD1, GUK1, ITPA, MMP11, NEBL, NUDT1, OAZ1, POLR2H, PSMB4, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A


*hsa-miR-30b

miR-30

20

ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, GPX4, GSTP1, GTF2IRD1, ITPA, MDK, NDK, OAZ1, PSMB4, S100A11, SLC7A11, USP22, VKORC1, ZNF37A


*hsa-miR-30c

miR-30

15

ANXA2, CSTB, GPATCH3, GSTP1, GTF2IRD1, ITPA, MDK, NDK, OAZ1, PSMB4, S100A11, SLC7A11, UBA6, VKORC1, ZNF37A


*hsa-miR-30d

miR-30

25

ANXA2, ATP6V0B, BHLHE40, C7orf28A, CAPG, CDC42SE1, CSTB, DAP, DDIT4, GPATCH3, GPX1, GTF2IRD1, MIF, MMP11, NEBL, POLR2H, PSMB4, RPL10, S100A11, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A


*hsa-miR-30e

miR-30

17

ATP6V0B, BHLHE40, C7orf28A, CAPG, CSTB, DAP, GPATCH3, GPX1, MMP11, NEBL, NUDT1, OAZ1, POLR2H, RPL10, TBCD, VKORC1, ZNF37A


hsa-miR-32

miR-32

5

C7orf28A, ODC1, PSMD8, RPL10, TBCD


*hsa-miR-34b

miR-34

12

BUD31, CANX, EIF3B, FTL, GTF3C1, IFITM1, PHB, PSMC4, PUF60, RPL34, SRD5A3, WDR36


hsa-miR-99a

miR-99

19

ANXA2, CSTB, DDIT4, GPATCH3, GSTP1, GTF2IRD1, MDK, MIF, NDK, NEBL, OAZ1, POLR2H, S100A11, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A


mmu-miR-10b

miR-10

2

Ras-Like protein, WDR36


mmu-miR-151

miR-151

13

ATP6V0B, BHLHE40, C7orf28A, CAPG, GTF2IRD1, MIF, MMP11, NUDT1, OAZ1, POLR2H, RPL10, TBCD, VKORC1


*mmu-miR-342

miR-342

21

ABHD12, ARPC1B, CLIC1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, NAP1L4, ODC1, PSMB2, PSMC4, PSMD8, PUF60, RPL10, RPL34, RPS9, SRD5A3, TGFBI, TUFM, Wilm's tumor-related protein


rno-miR-140

miR-140

1

NDK


rno-miR-151

miR-151

16

ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, GTF2IRD1, ITPA, MDK, MMP11, PSMB4, S100A11, SLC7A11, USP22, ZNF37A


*miRNAs are selected as cancer-mediators based on the literature.

Li et al. BMC Medical Genomics 2011 4:44   doi:10.1186/1755-8794-4-44

Open Data