Research article
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
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* Corresponding authors: Francesco M Marincola FMarincola@mail.cc.nih.gov - Yung-Chi Cheng yccheng@yale.edu
- † Equal contributors
1 Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, Maryland, 20892, USA
2 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
3 Department of Oncology, Biology and Genetics and Department of Internal Medicine, University of Genoa and National Cancer Research Institute of Genoa, Largo Rosanna Benzi 16132 Genoa, Italy
4 Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
5 Cell Therapy Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892, USA
6 Office of Cancer Complementary and Alternative Medicine, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
BMC Medical Genomics 2011, 4:38 doi:10.1186/1755-8794-4-38
Published: 11 May 2011Additional files
Additional file 1:
Table S1. qPCR mouse primers used.
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Additional file 2:
Table S2. Summary of differentially expressed genes among treatment groups in different tissues.
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Additional file 3:
Figure S3. Stacked bar chart summarizing the 15 most affected canonical pathways according to IPA based on genes with annotated function differentially expressed (t-test cutoff p-value < 0.05, pt test p-value < 0.001) in tumor biopsies between PBS control group and the treatment groups: (a) PHY906 (b) CPT-11 (c) PHY906+CPT-11. Finally, differences between PHY906+CPT-11 compared to CPT-11 alone are shown in (d).
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Additional file 4:
Data S4. Cytotoxicity of PHY906 on HepG2 after three days exposure.
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