Analysis Pipeline. In a preprocessing step, validated SNPs and focal CNAs are combined into a mutation matrix. This matrix is fed into the winnow algorithm, which scores each gene pair by exclusivity, indicated by edge scores in a graph. This graph is then searched for modules up to a specified size and the algorithmic significance is calculated for each potential module. Finally, the most significant modules are reported.
Miller et al. BMC Medical Genomics 2011 4:34 doi:10.1186/1755-8794-4-34