Table 4

Genes identified in figure 4 with p-value < 0.05 by t-test

Gene Symbol

ovarian

p-value

lung

p-value

Betweenness

(mean = 3.8E-4)

Degree

(mean = 9.71E-4)

Connected nodes


KRAS

(v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)

6.23E-04

0.001393

0.00703

0.009226


TP53

(tumor protein p53)

0.011083

1.82E-04

0.046039

0.029049


AKT

(v-akt murine thymoma viral oncogene homolog)

1.87E-05

4.60E-06

0.009775

0.013091

V


GSK3β

(glycogen synthase kinase 3 beta)

3.09E-06

1.81E-04

0.003932

0.006483

V


WNT

(wingless-type MMTV integration site family)

0.009519

0.002234

1.51E-04

4.99E-04


PTEN

(phosphatase and tensin homolog)

0.001494

0.016189

0.002282

0.002618

V


DVL

(dishevelled, dsh homolog 1 (Drosophila))

1.95E-08

1.80E-05

0.001653

0.002618

V


HES1

(hairy and enhancer of split 1, (Drosophila))

0.005831

2.82E-07

4.08E-04

0.001745


Genes listed in table 4 are significant in both ovarian and lung expression data with p-value < 0.05. Four connected nodes were identified. These genes also had significant betweenness and degree centrality. PTEN was the first tumor suppressor gene to be identified in the phosphatase family, and the principal function of its gene product appears to be dephosphorylation of the second messenger PIP3 [43]. The expression of PTEN in two independent glioblastoma cell lines results in the disruption of downstream signaling of PI3K to Akt and Bad [44]. Thus, when PTEN is present, Akt phosphorylation is blocked and apoptosis mechanisms may be activated. The importance of Akt and PTEN genes are as well revealed by this work, which illustrates the accuracy and efficiency of our algorithm.

Chao et al. BMC Medical Genomics 2011 4:23   doi:10.1186/1755-8794-4-23

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