One experimental result of identified pathways from ovarian expression data. This diagram shows one of identified signature pathways. Genes represented by red squares indicate the connected nodes; that is, these genes connect pathways. Connected nodes are key factors for joining two or more metabolic pathways or passing down signals. The blue square indicates the PI3K/AKT pathway. The PI3K/AKT cascade plays an important role in the resistance of ovarian cancer cells to cisplatin in vitro. This pathway is therefore an attractive target for the development of novel anticancer agents.
Chao et al. BMC Medical Genomics 2011 4:23 doi:10.1186/1755-8794-4-23