Table 2

Sample size estimates for GWAS of diabetic retinopathy with power estimates for the individual sites and with combined data

eMERGE site

Estimated number of diabetic retinopathy cases and controls

Power for GWAS, p < 10-8, MAF = .10 OR = 2.5

Marshfield

367/569

.424

Northwestern

150/1262

.243

Mayo

83/3412

.101

Group Health

324/667

.449

Vanderbilt

260/500

.270

Combined

1184/6410

.999


McCarty et al. BMC Medical Genomics 2011 4:13   doi:10.1186/1755-8794-4-13

Open Data