Open Access Research article

Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

Margarethe Biong1, Inger T Gram2, Ilene Brill3, Fredrik Johansen1, Hiroko K Solvang14, Grethe IG Alnaes1, Toril Fagerheim5, Yngve Bremnes2, Stephen J Chanock67, Laurie Burdett7, Meredith Yeager7, Giske Ursin89 and Vessela N Kristensen110*

Author Affiliations

1 Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello 0310, Oslo, Norway

2 Institute of Community Medicine, University of Tromsø, Breivika, Norway

3 University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama, USA

4 Department of Biostatistics, Institute of Basic Medical Science, University of Oslo, Oslo, Norway

5 Department of Genetics, University Hospital of North Norway, Tromsø; Norway

6 NCI, NIH, Pediatric Branch, Bethesda, USA

7 Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, Bethesda, MD, 20892, USA

8 Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

9 Department of Preventive Medicine University of Southern California Keck School of Medicine, Los Angeles, CA, USA

10 Faculty of Medicine, (Faculty Division Ahus), UiO, Oslo, Norway

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BMC Medical Genomics 2010, 3:9  doi:10.1186/1755-8794-3-9

Published: 19 March 2010

Additional files

Additional file 1:

Haplotype analysis stratified by current HT use. Associations of the common haplotypes with IGF1, IGFBP3 and mammographic density levels stratified by current HT use.

Format: XLS Size: 25KB Download file

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Additional file 2:

Haplotype analysis stratified by never/past HT use. Associations of the common haplotypes with IGF1, IGFBP3 and mammographic density levels stratified by never past HT use.

Format: XLS Size: 25KB Download file

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Additional file 3:

IGF haplotype association stratified by age and BMI. Significant association of IGF1 haplotype 4 with ABDEN stratified by age and BMI tertiles.

Format: XLS Size: 19KB Download file

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Additional file 4:

Associations of single SNPs with IGF1, IGFBP3 levels, IGFratio, and mammographic density. PDEN-Percent Density, ABDEN-Absolute density. LSMEANS-Least squares Means. Measurements of mammographic density are boxcox transformed.

Format: XLS Size: 43KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data