The associations between diseases, proteins, and peptides in mspecLINE. First, we constructed sets of all MeSH disease descriptors and all unique MeSH protein descriptors for proteins in PeptideAtlas. Next, we associated diseases with proteins by calculating pairwise NMD values between disease and protein descriptors. Last, we incorporated protein-peptide mappings from PeptideAtlas to construct lists of possible disease-related peptides that are observable in a mass spectrometer.
Handcock et al. BMC Medical Genomics 2010 3:7 doi:10.1186/1755-8794-3-7