Table 1

Case-control association results for significant and suggestive SNPs in the PLA2G4C gene region tested across 3 independent populations.

Population

SNP

Allele

Case Frequency

Control Frequency

Allele p-value

Genotype p-value

Allelic OR (95% CI)


US Hispanic

(73 cases, 292 controls)

rs8110925

G

0.18

0.085

7.92 × 10-4 a, b

5.66 × 10-5 b

2.4 (1.4-4.1)


rs2307276

A

0.11

0.036

5.45 × 10-3 b

0.01

3.2 (1.6-6.5)


rs1366442

A

0.49

0.36

0.01

0.03

1.7 (1.2-2.4)


rs11564620

G

0.09

0.08

0.55 c

0.63 c

1.1 (0.6-2.1)



US White

(147 cases, 157 controls)

rs8110925

G

0.058

0.057

0.92

0.59

1.0 (0.5-2.0)


rs2307276

A

0.031

0.041

0.87

0.86

0.8 (0.3-1.8)


rs1366442

G

0.4

0.42

0.5

0.02

0.9 (0.6-1.2)


rs11564620d

G

0.14

0.07

6.98 × 10-3

1.03 × 10-3 b

2.1 (1.2-3.6)



US Black

(79 cases, 166 controls)

rs8110925

G

0.22

0.21

0.58 e

0.83 e

1.1 (0.7-1.7)


rs2307276

A

0.093

0.14

0.22

0.49

0.6 (0.3-1.2)


rs1366442

G

0.42

0.4

0.92

0.94

1.1 (0.7-1.6)


rs11564620

G

0.25

0.21

0.47 c

0.36 c

1.2 (0.8-1.9)


aBolded numbers indicate p-value <0.05.

bMarker significant correcting for 8 tests (p < 0.006).

cSame allele trends in same direction as US Whites.

dp = 0.04 for deviation from Hardy-Weinberg Equilibrium.

eSame allele trends in same direction as US Hispanics.

Plunkett et al. BMC Medical Genomics 2010 3:62   doi:10.1186/1755-8794-3-62

Open Data