MetaCore network analyses. The top 47 genes that matched to the probes that were differentially expressed between HER2+ and HER2- samples (p-values < 0.01 and log2-fold change > |1.0|) in the 24K panel are enriched with genes (marked by red cycles) belonging to two distinct regulatory networks. a. The first network includes genes (marked by red cycles) functionally connected to MYC (c-Myc). b. The second network is enriched by genes (marked by red cycles) centered around TP53 (p53) and ESR1. c. The 8 genes differentially expressed in both the 24K and 1.5K panels (marked by red cycles) are all connected in a network that includes TP53 (p53), ESR1, and MYC (c-Myc) d. Symbol legend. Abbreviations for gene names presented in Figure 5 are defined in Additional File 1, Tables S1-S3.
Reinholz et al. BMC Medical Genomics 2010 3:60 doi:10.1186/1755-8794-3-60