FLCN expression negatively correlates with PGC-1α activation. A) The twenty most highly correlated gene sets with FLCN expression levels, followed by their respective Spearman rho correlation coefficients. Bold font indicates gene sets also shown in Figure 3. The dendrogram is based on gene set dissimilarity scores (see Materials and Methods). B) Plot of FLCN expression and the enrichment scores for the PGC gene set in tumors of the breast, cervix, colon, kidney, lung, lymph, ovary, pancreas, prostate, stomach, thyroid, and vulva, with tissue type-matched normal tissue. Data for A) and B) are from the Expression Project for Oncology - International Genomics Consortium.
Klomp et al. BMC Medical Genomics 2010 3:59 doi:10.1186/1755-8794-3-59