BHD tumors do not share the cytogenetic features of sporadic chromophobe RCC and renal oncocytoma. A) CGMA plot of BHD, CH, and ON tumor samples (columns) and chromosomal arms (rows) (p < 0.001). Blue indicates regions with a predicted copy number loss while red indicates regions with a predicted copy number gain or somatic chromosome pairing. The vertical dashed line separates oncocytoma samples with high cyclin D1 (CCND1) expression on the left from those with low expression on the right. B) Heatmap showing expression values for CCND1 and neighboring genes on chromosome 11q, with sample columns aligned as in part A. C) Relative gene expression for CCND1, with samples arranged as given in the columns of the previous parts A and B.
Klomp et al. BMC Medical Genomics 2010 3:59 doi:10.1186/1755-8794-3-59