Table 6

Top 10 Alzheimer Disease Genes ranked on Genotator score.

Gene

Score

Literature Support

Reference


APOE

513

Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

[52]

PSEN1

45.4

Early Onset Alzheimer's Disease with Spastic Paraparesis, Dysarthria and Seizures and N135 S Mutation in PSEN.

[53]

ACE

28.4

Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population.

[54]

PRNP

23.1

Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes.

[55]

BCHE

22.7

Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology.

[56]

APOC1

20.8

APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals

[57]

IL1B

19.9

Assessment of Alzheimer's disease case-control associations using family-based methods.

[58]

IL1A

19.5

Pharmacogenomics in Alzheimer's disease.

[59]

MTHFR

19.3

Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.

[60]

BDNF

17.5

Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease.

[61]


The table lists the title and reference of the research study supporting the gene-disease association together with the official gene symbol. A complete set of results is available online as Additional file 3.

Wall et al. BMC Medical Genomics 2010 3:50   doi:10.1186/1755-8794-3-50

Open Data