Table 1

Differentially expressed host genes which mapped to immune related responses.

Annotation

Name

Accession

Fold Difference


I Cytokine and chemokine-mediated immunity and signalling

lung i.n. vs spleen i.d.

lung i.n.vs lung i.d.


CD40 antigen

Cd40

NM_170702.2

3.0


Chemokine (C motif) ligand 1

Xcl1

NM_008510.1

4.0

8.0


Chemokine (C-C motif) ligand 1

Ccl1

NM_011329.1

9.7

6.7


Chemokine (C-C motif) ligand 2

Ccl2

NM_011333.1

3.2

2.2


Chemokine (C-C motif) ligand 3

Ccl3

NM_011337.1

4.3


Chemokine (C-C motif) ligand 4

Ccl4

NM_013652.1

7.4


Chemokine (C-C motif) ligand 5

Ccl5

NM_013653.1

3.4


Chemokine (C-C motif) ligand 7

Ccl7

NM_013654

17.9

6.9


Chemokine (C-C motif) ligand 8

Ccl8

NM_021443.1

10.7

4.3


Chemokine (C-C motif) ligand 12

Ccl12

NM_011331

2.7


Chemokine (C-C motif) ligand 24

Ccl24

NM_019577.2

-4.3


Chemokine (C-X-C motif) ligand 1

Cxcl1

NM_008176.1

2.9


Chemokine (C-X-C motif) ligand 2

Cxcl2

NM_009140

2.4


Chemokine (C-X-C motif) ligand 9

Cxcl9

NM_008599

12.6


Chemokine (C-C motif) receptor 3

Ccr3

NM_009914.2

-2.1


Chemokine (C-X-C motif) receptor 6

Cxcr6

NM_030712.1

5.3


Colony stimulating factor 1 (macrophage)

Csf1

NM_007778.1

2.1


Colony stimulating factor 3 receptor (granulocyte)

Csf3r

NM_007782.1

-2.1


Cytokine inducible SH2-containing protein

Cish

NM_009895.2

4.7

4.5


Interferon gamma

Ifng

NM_008337.1

5.2


Interferon gamma receptor 2

Ifngr2

NM_008338.2

3.2


Interleukin 18

Il18

NM_008360.1

-4.3


Lymphocyte-activation gene 3

Lag3

NM_008479.1

2.8

5.0


Protein tyrosine phosphatase, non-receptor type 6

Hcph

NM_013545.1

2.0


Signal-regulatory protein alpha

Ptp4a3

NM_008975.2

-2.1


Transferrin

Trf

NM_133977.1

-8.8


Tumor necrosis factor

Tnf

NM_013693

2.6



II Inflammation mediated pathway


Cyclin-dependent kinase inhibitor 1A (P21)

Cdkn1a

NM_007669.2

2.2


Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

Fgr

NM_010208

-3.5


Integrin alpha 9

Itga9

NM_133721.1

-3.0


Procollagen, type XIV, alpha 1

Col14a1

AK052963

-3.4


Prostaglandin-endoperoxide synthase 1

Ptgs1

NM_008969.1

-7.0


Vav2 oncogene

Vav2

NM_009500.1

-3.7




III Interferon-stimulated genes


2'-5' oligoadenylate synthetase-like 2

Oasl2

NM_011854.1

4.0

3.3


2'-5' oligoadenylate synthetase 1G

Oas1g

NM_011852.2

3.2


Guanylate nucleotide binding protein 1

Gbp1

NM_010259.1

2.2

5.5


Guanylate nucleotide binding protein 2

Gbp2

NM_010260.1

4.4


Guanylate nucleotide binding protein 4

Gbp4

NM_018734.2

3.2


Interferon activated gene 202B

Ifi202b

NM_008327.1

2.4


Interferon-induced protein with tetratricopeptide repeats 2

Ifit2

NM_008332.2

2.0


Interferon-induced protein with tetratricopeptide repeats 3

Ifit3

NM_010501.1

3.9


Interferon regulatory factor 8

Icsbp1

NM_008320.2

3.2


Signal transducer and activator of transcription 1

Stat1

NM_009283

3.0


SLAM family member 8

Slamf8

XM_129596.2

5.0



IV T cell activation


Beta-2 microglobulin

B2m

NM_009735.2

2.3


Cathepsin S

Ctss

NM_021281.1

3.0


CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

li

BC003476

5.6


CD86 antigen

Cd86

NM_019388.2

-2.3

2.5


CD274 antigen

Pdcd1lg1

NM_021893.2

2.5

3.8


Cytotoxic T-lymphocyte-associated protein 4

Ctla4

NM_009843.2

3.9


Histocompatibility 2, Q region locus 6

H2-Q6

NM_207648

3.0


Interferon gamma inducible protein 30

Ifi30

NM_023065.2

2.5


Histocompatibility 2, class II antigen A, beta 1

H2-Ab1

NM_207105.1

7.7


Histocompatibility 2, D region locus 1

H2-D1

NM_010380.2

3.0


Histocompatibility 2, class II, locus Dma

H2-DMa

NM_010386

3.9


Histocompatibility 2, class II, locus Mb1

H2-DMb1

NM_010387.2

5.8


Histocompatibility 2, class II, locus Mb2

H2-DMb2

NM_010388

5.5


Histocompatibility 2, class II antigen E alpha

H2-Ea

NM_010381.2

6.5


Histocompatibility 2, class II antigen E beta

H2-Eb1

NM_010382.1

7.9


Histocompatibility 2, K1, K region

H2-K1

NM_001001892.1

3.0


Histocompatibility 2, M region locus 3

H2-M3

NM_013819.1

2.6


Histocompatibility 2, Q region locus 2

H2-Q2

NM_010392.2

2.7


Histocompatibility 2, Q region locus 5

H2-Q5

NM_010393.1

2.9


Histocompatibility 2, T region locus 10

H2-T10

NM_010395.5

2.5


Histocompatibility 2, T region locus 23

H2-T23

NM_010398.1

2.9


Histocompatibility 2, T region locus 9

H2-T9

NM_010399

3.1


Peroxiredoxin 5

Prdx5

NM_012021

2.2



V Other ligand-mediated signalling


Calcitonin/calcitonin-related polypeptide, alpha

Calca

NM_007587

2.0


E2F transcription factor 2

E2f2

NM_177733.2

-3.4


Endothelin 1

Edn1

NM_010104.2

2.1


Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

Edg5

NM_010333

2.1


FMS-like tyrosine kinase 1

Flt1

NM_010228.2

3.9


Granulin

Grn

NM_008175.2

2.8


Mannose-6-phosphate receptor, cation dependent

M6pr

NM_010749.4

2.2


Paired-Ig-like receptor A1

Pira1

NM_011087.1

-2.1


Paired-Ig-like receptor A11

Pira11

NM_011088.1

-2.1


Paired-Ig-like receptor A3

Pira3

NM_011090.1

-3.8


Paired-Ig-like receptor A4

Pira4

NM_011091.1

-2.4


Peroxisome proliferator activated receptor gamma

Pparg

NM_011146.1

-2.7


Pre-B-cell colony-enhancing factor 1

Pbef1

NM_021524.1

2.7


Secretoglobin, family 1A, member 1 (uteroglobin)

Scgbla1

NM_011681.1

40.0


Solute carrier family 1 (glial high affinity glutamate transporter), member 3

Slcla3

NM_148938.2

-2.5


Spermine oxidase

Smox

NM_145533.1

-2.7


Vascular endothelial growth factor A

Vegfa

NM_009505.2

2.5



VI Complement-mediated


Complement component 1, q subcomponent, alpha polypeptide

C1qa

NM_007572

-3.6


Complement component 1, q subcomponent, beta polypeptide

C1qb

NM_009777.1

-4.5

3.8


Complement component 1, q subcomponent, C chain

C1qg

NM_007574.1

-4.3


Complement component 2 (within H-2S)

C2

NM_013484.1

-3.3


Complement component 3

C3

NM_009778.1

4.2


Complement component 4A (Rodgers blood group)

Slp

NM_011413

2.3


Complement component 6

C6

NM_016704.1

-2.6


Complement factor B

H2-Bf

NM_008198.1

11.5

6.5


Complement factor properdin

Pfc

XM_135820.3

-10.3


Four and a half LIM domains 1

Fhl1

NM_010211.1

2.3



VII Apoptosis


B-cell leukemia/lymphoma 2 related protein A1b

Bcl2a1b

NM_007534

2.5


B-cell leukemia/lymphoma 2 related protein A1d

Bcl2a1d

NM_007536

2.7


Caspase 1

Casp1

NM_009807.1

4.0


Caspase 4, apoptosis-related cysteine peptidase

Casp4

NM_007609.1

2.4


Epithelial membrane protein 3

Emp3

NM_010129.1

2.3


Lectin, galactose binding, soluble 1

Lgals1

NM_008495.1

4.0


Thioredoxin 1

Txn1

NM_011660.3

2.1



VIII Signal transduction


AXL receptor tyrosine kinase

Axl

NM_009465.2

-6.4


C-mer proto-oncogene tyrosine kinase

Mertk

NM_008587

-3.7


C-type lectin domain family 4, member a1

BC049354

XM_194289.2

-3.0


C-type lectin domain family 4, member b1

Clec4b1

NM_027218.1

-3.9


C-type lectin domain family 4, member a3

Clec4a3

NM_153197.3

-2.1


CD63 antigen

Cd63

NM_007653.1

3.3


CD81 antigen

Cd81

NM_133655.1

-4.6


CD93 antigen

C1qr1

NM_010740.1

3.7


CD207 antigen

Cd207

NM_144943.2

-2.2


Chemokine (C-X-C motif) ligand 15

Cxcl15

NM_011339.1

5.0


Colony stimulating factor 1 receptor

Csf1r

NM_007779.1

-9.5


Integrin beta 5

Itgb5

NM_010580

-3.4


Neutrophilic granule protein

Ngp

NM_008694.1

-8.9


Plasminogen activator, urokinase

Plau

NM_008873.2

2.2


S100 calcium binding protein A9 (calgranulin B)

S100a9

NM_009114.1

-4.2


Thrombomodulin

Thbd

NM_009378.1

4.6



IX Other cell communication


Cadherin 1

Cdh1

NM_009864.1

4.8

3.2


Hematological and neurological expressed sequence 1

Hn1

NM_008258.1

2.3


Intercellular adhesion molecule

Icam1

NM_010493.2

2.3


Lectin, galactoside-binding, soluble, 3 binding protein

Lgals3bp

NM_011150.1

4.0


Proteolipid protein 2

Plp2

NM_019755.2

2.5


Purine-nucleoside phosphorylase

Pnp

NM_013632.2

3.2



X Natural killer cell-mediated immunity


Fc fragment of IgG, low affinity IIIa, receptor

Fcrl3

NM_144559.1

3.8


Killer cell lectin-like receptor subfamily C, member 1

Klrc1

NM_010652

3.8


Killer cell lectin-like receptor subfamily K, member 1

Klrk1

NM_033078.2

2.0


Natural killer cell group 7 sequence

Nkg7

NM_024253.3

3.7



XI Other host immune responses


Allograft inflammatory factor 1

Aif1

NM_019467.2

-2.8

2.7


ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Abcc3

XM_358306.1

-10.6


Carboxylesterase 3

Ces3

NM_053200.1

2.9


Catalase

Cat

NM_009804.1

-2.3


Cathelicidin antimicrobial peptide

Camp

NM_009921.1

-18.3


Cathepsin E

Ctse

NM_007799

-2.3


CD59a antigen

Cd59a

NM_007652.2

-3.0


CD93 antigen

C1qr1

NM_010740.1

3.7


CD163 antigen

Cd163

NM_053094.1

-10.1


CD244 natural killer cell receptor 2B4

Cd244

NM_018729

-3.3


Coagulation factor X

F10

NM_007972.2

2.6


Fc receptor, IgG, alpha chain transporter

Fcgrt

NM_010189.1

-4.8


Glutathione peroxidase 1

Gpx1

NM_008160.1

-2.7


Glutathione peroxidase 3

Gpx3

NM_008161.1

-2.0


Glutathione S-transferase, mu 2

Gstm2

NM_008183.2

5.0


Glutathione S-transferase omega 1

Gsto1

NM_010362.1

-2.1


Guanine nucleotide binding protein (G protein), gamma 2 subunit

Gng2

NM_010315.2

2.9


Guanine nucleotide binding protein (G protein), gamma 10

Gng10

NM_025277

2.4


Hemochromatosis

Hfe

NM_010424.2

-5.3


Immunoresponsive gene 1

Irg1

XM_127883

2.8


Interferon, alpha-inducible protein 27

2310061N23Rik

NM_029803

3.9


Interferon induced transmembrane protein 2

Ifitm2

NM_030694.1

-2.0


Interferon induced transmembrane protein 6

Ifitm6

XM_133956.3

-5.0


Kruppel-like factor 6

Copeb

NM_011803.1

2.5


Lipocalin 2

Lcn2

NM_008491.1

-5.1


LPS-induced TN factor

Litaf

NM_019980

2.6


Lymphocyte antigen 96

Ly96

NM_016923.1

-2.2


Lysozyme

Lyzs

NM_017372

2.5


Mannose receptor, C type 1

Mrc1

NM_008625.1

-7.6


Membrane-associated ring finger (C3HC4) 8

Mir

NM_027920.3

-2.2


Myeloperoxidase

Mpo

NM_010824.1

-3.3


Peptidoglycan recognition protein 1

Pglyrp1

NM_009402.1

-2.5


Peripheral myelin protein

Pmp22

NM_008885.1

3.5


Peroxidasin homolog (Drosophila)

2310075M15Rik

XM_283052

2.0


Peroxiredoxin 2

Prdx2

NM_011563.2

-3.5


Peroxiredoxin 5

Prdx5

NM_012021

2.4


Phytoceramidase, alkaline

Phca

NM_025408.1

-2.1


Prosaposin

Psap

NM_011179

-2.1

2.3


Regulator of G-protein signaling 1

Rgs1

NM_016846.2

4.8


S100 calcium binding protein A4

S100a4

NM_011311.1

4.6


S100 calcium binding protein A8 (calgranulin A)

S100a8

NM_013650.1

-4.4


SAM domain and HD domain, 1

Samhd1

BC067198

2.8


Selenoprotein P, plasma, 1

Sepp1

NM_009155.3

-2.4


Serum amyloid A 3

Saa3

NM_011315

4.5


Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Slc11a1

NM_013612.1

-2.2


Superoxide dismutase 2, mitochondrial

Sod2

NM_013671.2

2.9


Surfactant associated protein A1

Sftpa1

NM_023134.3

2.5


Surfactant associated protein D

Sftpd

NM_009160.1

10.4



XII Genes mentioned in text but not categorized by Panther


Chemokine (C-X-C motif) ligand 12

Cxcl12

NM_013655.2

4.0


Chemokine (C-X-C motif) ligand 13

Cxcl13

NM_018866.1

2.1


Chemokine (C-X-C motif) ligand 16

Cxcl16

NM_023158

4.1


Expressed sequence AA467197

AA467197

NM_001004174.1

8.8


Lymphocyte antigen 6 complex, locus A

Ly6a

NM_010738.2

5.8

4.7


Immunity-related GTPase family, M

Irgm

NM_008326.1

2.8


Lymphocyte antigen 6 complex, locus C

Ly6c

NM_010741

3.0


Mus musculus lactotransferrin

Ltf

NM_08522.2

-16.8


Proteasome (prosome, macropain) subunit, beta type 9

Psmb9

NM_013585.1

2.9


Proteasome (prosome, macropain) subunit, beta type 8

Psmb8

NM_010724

3.2


Proteasome (prosome, macropain) subunit, beta type 10

Psmb10

NM_013640.1

2.4


Serine (or cysteine) peptidase inhibitor, clade A, member 3G

Serpina3g

NM_009251.1

14.8


Three prime repair exonuclease 1

Trex1

NM_011637.4

2.0


Tryptophanyl-tRNA synthetase

Wars

NM_011710.2

2.2


Tumor necrosis factor (ligand) superfamily, member 13b

Tnfsf13b

NM_033622

3.1

3.0


Ubiquitin D (Ubd)

Ubd

NM_023137.2

4.2


Ubiquitin specific peptidase 18

Usp18

NM_011909.1

2.6


Expression was analyzed using Genome Studio and classified by immune function through Panther Immune Processes. Genes not classified by Panther but clearly related to immune processes were added manually (section XII). All processes were analyzed statistically with a p-value ≤ 0.05.

Lee et al. BMC Medical Genomics 2010 3:46   doi:10.1186/1755-8794-3-46

Open Data