Effect of HSP90 inhibition by 17AAG in a biopsy from a breast cancer patient. A) Cell cycle analysis in untreated cells and cells treated with 17AAG for 24 H and 48 H, exhibiting G2/M arrest at both time points. B) Validation of a group of genes from the signature of response to 17AAG in the primary tumor cells. All these genes showed increased expression after treatment >2fold at 24 H or 48 H, as occurred in the sensitive cell lines.
Zajac et al. BMC Medical Genomics 2010 3:44 doi:10.1186/1755-8794-3-44