Table 5

Characteristics of genes with novel association to castration-recurrence in vivo

Associated with

Associated with



Gene*

S or PM†

Reg. by A‡

Spec. to P§

CaPII

GG¶

Prog.**

Mets††

CR‡‡

Gene

S or PM

Reg. by A

Spec. to P

CaP

GG

Prog.

Mets

CR


ABHD2

PM

Y↑

-

Y↑

-

-

-

-

NKX3-1

-

Y↑

Y

-

-

-

Y

-

ACY1

-

-

-

-

-

-

-

-

ODC1

-

Y↑

-

Y↑

-

Y↓

-

Y↑

AQP3

PM

-

-

-

-

-

-

-

OPRK1

PM

-

-

-

-

-

-

-

ATP5G2

-

-

-

-

-

-

-

-

OR51E2

PM

-

-

Y↑

-

-

-

-

B2M

S&PM

Y↑

-

-

-

Y↑

-

Y↓

P4HA1

-

Y

-

-

-

-

-

-

BNIP3

-

-

-

Y↓

-

-

-

-

PCGEM1

-

Y↑

Y

Y↑

-

Y↑

-

-

BTG1

-

Y↓

-

-

-

-

-

-

PCOTH

-

-

Y

Y↑

-

Y↑

-

-

C17orf45

-

-

-

-

-

-

-

-

PGK1

-

Y↑

-

Y↓

Y↑

-

Y ↑↓§§

-

C19orf48

S

Y↑

-

-

-

-

-

-

PIK3CD

-

-

-

-

-

-

Y↑

Y↑

C1orf80

-

-

-

-

Y↑

-

-

-

PJA2

-

-

-

-

-

-

-

-

CAMK2N1

-

Y↓

-

-

Y↑

Y↑

-

-

PLCB4

PM

-

-

-

-

-

-

-

CCNH

-

-

-

-

-

-

-

-

PPP2CB

-

-

-

Y↓

-

-

-

-

CCT2

-

-

-

-

-

-

-

-

PPP2R1A

-

-

-

-

-

-

-

-

CD151

PM

-

-

-

-

Y↑

Y↑

-

PSMA7

-

-

-

Y↓

-

-

-

-

COMT

-

-

-

-

-

Y↓

-

-

PTGFR

PM

-

-

-

-

-

-

-

CUEDC2

-

-

-

-

-

-

-

-

QKI

-

-

-

-

-

-

-

-

CXCR7

PM

Y↓

-

-

-

-

Y↑

Y↑

RAMP1

PM

-

Y

Y↑

-

-

-

-

DHRS7

PM

-

-

-

-

-

Y↓

-

RNF208

-

-

-

-

-

-

-

-

EEF1A2

-

Y↑

-

Y↑

-

-

-

-

RPL11

-

-

-

-

-

-

Y↓

-

EEF2

-

-

-

-

-

-

-

-

RPL28

-

-

-

-

-

-

-

-

ELOVL5

PM

Y

Y

Y↓

-

-

-

-

RPS11

-

-

-

-

-

-

Y↓

-

ENDOD1

S

Y↑

-

-

-

-

-

-

RPS18

-

-

-

Y↑

-

-

-

-

ENO2

PM

-

-

-

-

-

-

-

RPS3

-

-

-

-

-

-

-

-

ENSG00000210082

-

-

-

-

-

-

-

-

S100A10

PM

-

-

-

-

-

-

-

ENSG00000211459

-

-

-

-

-

-

-

-

SBDS

-

-

-

-

-

Y↑

-

-

FGFRL1

PM

-

-

-

-

-

-

-

SELENBP1

-

Y↓

-

Y↓

-

-

-

-

FKBP10

-

-

-

-

-

-

-

-

SERINC5

-

-

-

-

-

-

-

-

GALNT3

-

-

-

Y↑

-

Y↓

-

-

SF3A2

-

-

-

-

-

-

Y↑

-

GAS5

-

-

-

-

-

-

-

-

SFRS2B

-

-

-

-

-

-

-

-

GLO1

-

-

-

Y↑

Y↑

Y↑

-

-

SH3BP5L

-

-

-

-

-

-

-

-

GNB2L1

PM

-

-

-

-

-

Y↑

-

SLC25A4

-

-

-

Y↑

-

-

-

-

GRB10

PM

-

-

-

-

-

-

-

SLC25A6

-

-

-

Y↑

-

-

-

-

H2AFJ

-

-

-

-

-

-

-

-

SNX3

-

-

-

-

Y↑

-

-

-

HES6

-

-

-

-

-

-

Y↑

Y↑

SPIRE1

-

-

-

-

-

-

-

-

HLA-B

PM

-

-

-

-

-

-

-

SPON2

S

-

Y

Y↑

-

-

-

-

HMGB2

-

-

-

-

-

-

-

Y↑

STEAP1

PM

-

Y

Y↑

-

-

-

-

HN1

-

-

-

-

-

-

Y↑

-

SYNC1

-

-

-

-

-

-

-

-

HSD17B4

-

Y↑

-

Y↑

-

-

-

-

TFPI

S

-

-

-

-

-

-

-

LOC644844

-

-

-

-

-

-

-

-

TK1

-

-

-

-

-

-

Y↑

-

MAOA

-

Y

-

-

Y↑

-

-

-

TKT

-

-

-

-

-

-

-

-

MARCKSL1

PM

-

-

Y↑

-

-

-

-

TMEM30A

S&PM

-

-

-

-

Y↑

-

-

MDK

S&PM

Y↓

-

Y↑

-

-

-

Y↑

TMEM66

S&PM

Y↑

-

-

-

-

-

-

MT-CO3

-

-

-

-

-

-

-

-

TPD52

-

Y↑

Y

Y↑

-

Y↑

Y↓

-

MT-ND3

-

-

-

-

-

-

-

-

TRPM8

PM

Y↑

-

Y↑

-

-

-

Y↓

NAAA

-

-

-

-

-

-

-

Y↑

UTX

-

-

-

-

-

-

-

-

NAT14

PM

-

-

-

-

-

-

-

VPS13B

PM

-

-

-

-

-

Y↑

-

NELF

PM

-

-

-

-

-

-

-

WDR45L

-

-

-

-

-

-

-

-

NGFRAP1

-

-

-

Y↓

-

-

-

-

YWHAQ

-

-

-

-

-

-

-

-


* Human Genome Nomenclature Committee (HGNC)-approved gene names were used when possible. Non-HGNC-approved gene names were not italicized.

† S or PM, gene product is thought to be secreted (S) or localize to the plasma membrane (PM)

‡ Reg. by A, gene expression changes in response to androgen in prostate cells

§ Spec. to P, gene expression is specific to- or enriched in- prostate tissue compared to other tissues

II CaP, gene is differentially expressed in prostate cancer compared to normal, benign prostatic hyperplasia, or prostatic intraepithelial neoplasia

¶ GG, gene is differentially expressed in higher Gleason grade tissue versus lower Gleason grade tissue

** Prog., gene expression correlates with late-stage prostate cancer or is a risk factor that predicts progression

†† Mets, gene expression is associated with prostate cancer metastasis in human samples or in vivo models

‡‡ CR, gene is associated with castration-recurrent prostate cancer in human tissue or in vivo models, but exhibits an opposite trend of this report

§§ Y, yes; ↑, high gene expression; ↓, low gene expression

Romanuik et al. BMC Medical Genomics 2010 3:43   doi:10.1186/1755-8794-3-43

Open Data