Differentially expressed genes in DS vs euploid progenitors. A) Schematic representation of chromosome 21 differentially expressed genes in DS vs euploid progenitors. Genes are categorized according to GO classification or their hypothetical biological function. B) Bar graph representation of more pronounced deregulated gene pathways in the whole genome of DS vs euploids, after PANTHER analysis. Vertical bars indicate the number of differentially expressed genes per pathway. C) HeatMap showing the fold-change of cell cycle and cell cycle-related differentially expressed genes in DS vs euploid progenitors. Gray intensity is proportional to the fold-change; the bar on the right illustrates the association between fold-changes and grayscale. The genes are ranked from the most up-regulated (white) to the most down-regulated (black). D) qRT-PCR for crucial genes belonging to the most deregulated gene pathways are shown. Data are indicated as relative expression levels (Euploid EPCs = 1).
Costa et al. BMC Medical Genomics 2010 3:40 doi:10.1186/1755-8794-3-40