Figure 3.

Promoter methylation and CpG content of decitabine-responsive genes in MCF-7 cell line. Of eighteen decitabine-induced genes from the MCF-7 breast cancer cell line, three are highly methylated, five have intermediate methylation levels, and ten have low levels of methylation. Highly methylated, decitabine-responsive genes have lower promoter CpG content. With increasing levels of methylation, CpG content of responsive genes increases. For extremely CpG-dense promoters, only those with low methylation levels are up-regulated. These observations are in accord with the melanoma data.

Rubinstein et al. BMC Medical Genomics 2010 3:4   doi:10.1186/1755-8794-3-4
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