Defining decitabine-response by fold-change expression and delta expression. Panel A. Genes are stratified by promoter CpG content (increasing from left to right) and methylation level (low methylation in top row, high methylation in bottom row). Delta expression is plotted as a function of basal expression level. Upregulated genes are defined as those with >= 2-fold expression increase (left of diagonal line) and delta expression >= 5,000 (above horizontal line). Panel B. Percent of upregulated genes per CpG and methylation bin, with maximal up-regulation observed at high methylation and intermediate CpG content. Stars and circles indicate promoter categories with statistically significant enrichment or depletion in the number of up-regulated genes, respectively.
Rubinstein et al. BMC Medical Genomics 2010 3:4 doi:10.1186/1755-8794-3-4