Acquired resistance to AKT inhibition is associated with increased RAS signature. (A) generation of a cell line with acquired resistance to MK-2206 by culturing in increasing drug concentrations over 7 months. (B) Cells cultured in vehicle for 7 months remain sensitive to AKT inhibition. Cells with acquired resistance to MK-2206 show decreased pAKT (C) and increased pERK (D).
Loboda et al. BMC Medical Genomics 2010 3:26 doi:10.1186/1755-8794-3-26