Table 3

Genes specific to the erythroid leukaemias

Probeset

Gene

SAM results

Leukaemic samples*

d-score

p-value

FDR

T1

T2

T3

B1

B2

B3

M

E1

E2

E3

Mk1

MK2

Mk3

E-CE

G1E


Correlation with the G1E database

1416193_at

Car1

8.2

<0.001

0.02

-3.4

-2.1

-3.2

-3.0

-3.0

-3.2

-2.4

6.0

5.9

1.7

1.4

-2.1

3.0

1.2

1422316_at

Gp1ba

12.7

<0.001

0.01

-2.5

-2.1

-1.9

-1.9

-2.0

-2.4

-1.9

4.3

3.3

1.7

0.1

-0.1

3.7

2.9

1422817_at

Gp5

7.5

<0.001

0.03

-3.6

-2.3

-3.0

-3.0

-2.9

-2.8

-1.9

4.5

3.6

1.7

2.4

1.6

3.4

3.8

1424968_at

2210023G05Rik

12.3

<0.001

0.01

-2.4

-2.3

-2.1

-2.2

-2.2

-1.9

-1.9

4.4

5.5

5.1

-0.2

-1.1

1.4

1.3

1425677_a_at

Ank1

18.2

0.001

0.01

-1.5

-1.3

-1.3

-1.5

-1.1

-0.9

-1.0

3.1

3.6

3.3

-0.5

-1.1

0.1

-0.8

1416464_at

Slc4a1

11.6

<0.001

0.02

-2.3

-1.4

-2.0

-2.4

-2.7

-2.0

-1.2

4.7

4.6

1.7

-1.8

0.2

3.2

-2.4

1451675_a_at

Alas2

11.0

<0.001

0.02

-3.4

0.3

-0.9

-2.5

-3.8

-3.2

-1.3

4.9

4.9

1.7

-2.8

-0.5

3.5

-1.1

1418699_s_at

Fech

8.9

<0.001

0.02

-0.8

-1.0

-0.7

-1.4

-1.7

-1.5

-0.5

2.2

2.5

1.7

-0.2

0.0

1.3

-2.4

Genes potentially implicated in the disease ***

E

1417514_at

Ssx2ip

13.97

<0.001

0.01

-1.1

-0.8

-1.4

-0.3

-0.3

-0.5

-0.5

2.8

2.7

3.0

-2.4

-1.4

0.3

1.1

1460057_at

Gdf3

9.4

<0.001

0.01

-1.3

-1.2

-1.0

-1.3

-0.9

-1.0

2.0

2.2

2.4

2.8

-1.3

-1.3

-0.1

2.9

NS

1419665_a_at

Nupr1

8.7

<0.001

0.01

-1.5

-1.5

-1.3

-1.3

-1.3

-1.7

0.3

3.9

2.5

3.3

-0.9

-0.6

0.2

4.0

-

1443969_at

Irs2

6.5

<0.001

0.02

0.1

-0.1

-1.5

-0.2

-0.4

0.4

-1.0

1.1

2.1

1.4

-1.2

-0.5

-0.2

1.2

1417165_at

Mbd2

17.38

<0.001

0.01

-0.7

-0.1

-0.4

0.0

-0.1

-0.3

-0.6

1.3

1.3

1.3

-0.6

-0.7

-0.2

0.9

-

1449256_a_at

Rab11a

10.59

<0.001

0.01

-1.0

-0.3

-1.2

-0.6

-0.6

-0.3

-0.4

1.7

1.7

1.3

-0.3

-0.1

0.2

1.7

-

1417396_at

Podxl

6.5

<0.001

0.02

-0.8

-0.9

-1.0

-1.0

-0.9

-0.7

-1.0

1.3

1.6

1.7

1.6

0.2

-0.1

2.4

NS

EMk3

1422737_at

Ncoa3

4.1

0.003

0.10

-0.3

-1.2

-0.1

-0.5

-0.4

0.3

-0.3

1.5

0.4

0.8

0.0

-0.7

0.6

2.2

NS

1435458_at

Pim1

5.4

<0.001

0.06

-1.0

-1.3

-2.0

-0.6

-0.4

-0.4

-0.2

1.5

1.5

1.0

0.1

0.9

0.9

0.6

Genes selected for RT-PCR validation

1449232_at

Gata1

4.58

<0.001

0.03

-1.9

-1.9

-2.1

-2.1

-2.3

-2.7

-1.9

4.5

4.1

4.5

0.6

-1.4

2.5

0.4

1425571_at

Slamf1

9.9

<0.001

0.02

-1.3

-1.6

-1.7

-1.2

-1.6

-1.5

-2.0

4.1

3.0

1.7

-0.3

-1.2

1.9

4.8

-

1418493_a_at

Snca

10.2

<0.001

0.02

-3.3

-0.2

-1.0

-2.5

-3.2

-1.8

-1.5

4.6

4.2

1.7

-1.0

-0.7

2.7

-2.6

1418061_at

Ltbp2

15

<0.001

0.01

-0.7

-0.7

-0.7

-0.7

-0.8

-0.7

-0.9

2.2

1.5

1.7

-0.5

-0.8

1.4

2.0

NS

1419069_at

Rabgef1

25.0

<0.001

0.01

-0.5

-0.8

-0.4

-0.9

-1.3

-1.2

-0.8

2.2

2.3

2.3

-0.4

-0.4

-0.1

4.8

-

1427357_at

Cda

25.0

<0.001

0.01

-1.5

-1.6

-1.6

-1.7

-1.8

-0.6

-1.3

4.3

4.8

4.9

-1.6

-1.7

-0.7

6.0

-

1417152_at

Btbd14a

9.5

<0.001

0.02

-0.6

-0.9

-0.9

-0.9

-0.8

-0.9

-0.5

2.3

1.5

1.7

-0.4

-0.4

1.0

2.3

NS


* amplitude of deviation from the mean calculated from the RMA values

** ratio E-CE: mean of the deviation of E1, E2 and E3/erythroid control value

*** cell cycle/cell growth/development/angiogenesis/DNA repair/transcriptionregulation

Voisin et al. BMC Medical Genomics 2010 3:2   doi:10.1186/1755-8794-3-2

Open Data