Table 3

Cross-talk ranking values (CTRVs) and link values of significant proteins in PPAN.

No.

Protein

CTRV

Link

No.

Protein

CTRV

Link



1

IRAK1

108

140

31

IL1R1

21

21

2

TRAF6

83

124

32

FADD

19

55

3

NIK

77

89

33

GRB2

18

46

4

A20

61

61

34

TAK1

17

66

5

MYD88

59

107

35

SOCS1

17

17

6

TRAF2

58

198

36

TRIF

16

54

7

IKKα

55

83

37

TMED1

12

12

8

SIGIRR

53

73

38

CASP8

10

87

9

TLR4

53

53

39

TAB2

10

53

10

IKKγ

52

84

40

CAV1

10

44

11

IKKβ

47

97

41

TAB1

9

44

12

BCL10

43

62

42

TTRAP

8

8

13

UBE2N

41

41

43

ECSIT

8

50

14

IRAK4

38

112

44

CYLD

6

6

15

RIP

38

57

45

TNF

0

48

16

TRAF3

37

57

46

TNFR2

0

39

17

IRAK3

36

36

47

IKKε

0

29

18

ST2L

32

32

48

PELI2

0

19

19

TNIP3

32

32

49

IL1B

0

18

20

PTPN11

31

31

50

MEKK3

0

18

21

TIRAP

29

40

51

TRAM

0

18

22

TRAF4

27

27

52

IL1A

0

17

23

TOLLIP

26

47

53

IL1R2

0

17

24

RNF216

25

25

54

TRAF5

0

17

25

TNFR1

24

111

55

SOS1

0

10

26

RIP3

23

93

56

IRF3

0

9

27

TRADD

23

32

57

NOD2

0

0

28

TBK1

22

39

58

CD14

0

0

29

PELI1

21

49

59

SARM1

0

0

30

TANK

21

40

60

FLN29

0

0


To integrate the information from the complex PPANs, the cross-talk ranking values (CTRVs) at different time stages are summed up for each protein. In contrast with CTRVs, the values of link represent the total number of protein-protein associations at six time stages of each protein. It reveals that not all nodes with high connective degree will also have high CTRVs such as CASP8.

Yang et al. BMC Medical Genomics 2010 3:19   doi:10.1186/1755-8794-3-19

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