Flowchart of the proposed method to construct the protein-protein association network (PPAN). This flowchart depicts the process to construct the protein-protein association network (PPAN) and the afterward investigations in this study. The four key steps of PPAN construction are described in details in the text. The rough PPAN is set up from steps (1) and (2), and the refinement is then performed in steps (3) and (4) to obtain the refined PPAN.
Yang et al. BMC Medical Genomics 2010 3:19 doi:10.1186/1755-8794-3-19