Schematic diagram for reconstructing the protein-protein association. This diagram shows the basic concept of the reconstruction of protein-protein association. On the protein level, the interactions between proteins from the well-known database and experimental data were extracted. However, this kind of interactions only reflects all possible static connections without stimulus-specific response or temporal changes. Our model includes the gene expression patterns from different time course to infer the dynamic protein-protein associations and networks, suggesting a more significant and realistic method for network reconstruction of the living organism.
Yang et al. BMC Medical Genomics 2010 3:19 doi:10.1186/1755-8794-3-19