Open Access Research article

Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

Shih-Kuang Yang1, Yu-Chao Wang1, Chun-Cheih Chao2, Yung-Jen Chuang23, Chung-Yu Lan34 and Bor-Sen Chen1*

Author Affiliations

1 Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan

2 Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan

3 Department of Life Science, National Tsing Hua University, Hsinchu, 30013, Taiwan

4 Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan

For all author emails, please log on.

BMC Medical Genomics 2010, 3:19  doi:10.1186/1755-8794-3-19

Published: 24 May 2010

Additional files

Additional file 1:

Supplementary Table S1. The Gene Ontology annotations (biological process, molecular function, cellular component) for the 60 proteins of interest are shown in the xls file.

Format: XLS Size: 71KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Supplementary Methods.

Format: PDF Size: 113KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Supplementary Table S2. Investigation of the TNFα refined protein-protein association network

Format: PDF Size: 209KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Supplementary Table S3. Investigation of the IL-1 and TLR4 refined protein-protein association network.

Format: PDF Size: 181KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Supplementary Figures. Complete time series diagrams of the refined PPANs under TNFα stress from 0 to 8 hour are shown in Supplementary Figures.

Format: ZIP Size: 1.1MB Download file

Open Data