EPC gene signature relates to monocytes, while OECs are closely linked to endothelial cells. (A) Hierarchical clustering reveals two major branches: eEPCs are clustered together with monocytes, whilst OECs are grouped with DMECs. Distance represents the similarity of gene expression between different samples (the closer the more similar), and numbers in black indicate statistically significant number of transcripts that identify a cluster; numbers in blue are transcript cluster IDs: clusters 1-6 indicate specific transcripts for a cell type; clusters 7-10 indicate common transcripts for 2/3 cell types; and cluster 11 indicates transcripts present equally in all samples. (B) Heat map of top 30 highly expressed genes in eEPCs demonstrating that eEPCs share a similar gene signature with monocytes. (C) Heat map of top 30 highly expressed genes in OECs indicates a high degree of correlation between OECs and DMECs.
Medina et al. BMC Medical Genomics 2010 3:18 doi:10.1186/1755-8794-3-18