Table 2

Top scoring genes from ROC analysis.

Gene Symbol

Gene Title

Pathway

AUC score


CDC20

Cell division cycle 20

Cell cycle

0.99


RRM2

Ribonucleotide reductase M2 polypeptide

DNA synthesis

0.98


CCNB1

cyclin B1

Cell cycle G1 to S

0.98


MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

Mitotic spindle checkpoint

0.98


PRC1

protein regulator of cytokinesis 1

Mitotic spindle assembly

0.97


CDC2

cell division cycle 2

Cell Cycle G1 to S and G2 to M

0.97


CDKN3

cyclin-dependent kinase inhibitor 3

Cell Cycle

0.97


A high AUC score indicates a strong ability to distinguish between groups (in this case, to identify expressors of our genes of interest).

MacDermed et al. BMC Medical Genomics 2010 3:16   doi:10.1186/1755-8794-3-16

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