Open Access Research article

MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients

Dhara M MacDermed1*, Nikolai N Khodarev2, Sean P Pitroda2, Darrin C Edwards3, Charles A Pelizzari2, Lei Huang4, Donald W Kufe4 and Ralph R Weichselbaum2

Author Affiliations

1 The Scripps Research Institute and Scripps Translational Science Institute, 3344 N. Torrey Pines Court Ste. 300, La Jolla, CA, 92037, USA

2 Department of Radiation and Cellular Oncology, The University of Chicago, Duchossois Center for Advanced Medicine, 5758 S. Maryland Avenue, MC9006, Chicago, IL 60637, USA

3 Department of Radiology, The University of Chicago Medical Center. 5841 S. Maryland Ave., Chicago, IL 60637, USA

4 Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney St., Dana 830, Boston, MA 02115, USA

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BMC Medical Genomics 2010, 3:16  doi:10.1186/1755-8794-3-16

Published: 6 May 2010

Additional files

Additional File 1:

Figure S1. Algorithm used to select a short signature from our biologically derived set of genes correlated with MUC1 transfection.

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Additional File 2:

Table S1. 254 genes differentially expressed in MUC1 transfected cells.

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Additional File 3:

Table S2. The top two functional networks represented by 254 genes with expressional changes associated with MUC1 transfection.

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Additional File 4:

Figure S2. The top functional network represented by 42 selected genes with expressional changes associated with MUC1 transfection and prognostic significance in lung adenocarcinoma patients.

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