Research article
Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets
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* Corresponding author: Laszlo Nagy nagyl@med.unideb.hu
- † Equal contributors
1 Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
2 Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
3 Department of Dermatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
4 Clinical Genomics Center, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
5 Department of Rheumatology, Institute of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
6 2nd Department of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
BMC Medical Genomics 2010, 3:15 doi:10.1186/1755-8794-3-15
Published: 5 May 2010Additional files
Additional file 1:
List of genes, gene interaction analyses and detailed gene expression data. • Figure S1) List of genes that were measured on the TaqMan Low Density Arrays. • Figure S2) Inclusion and exclusion criteria of diseased patients and healthy controls. • Figure S3) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between IBD and controls. • Figure S4) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between psoriasis and controls. • Figure S5) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between RA and controls. • Figure S6) Number of diseased patients with gene expression levels outside the range of the mean ± SD or 2 SD in control sample. Based on Figure 6. • Figure S7) Stratifying IBD: The results of the RT-QPCR measurements for each gene that showed significant differences between Crohn's disease vs Ulcerative colitis patients. • Figure S8) Stratifying Psoriasis: The results of the RT-QPCR measurements for each gene that showed significant differences between arthritis negative vs positive forms. • Figure S9) Stratifying RA: The results of the RT-QPCR measurements for each gene that showed significant differences between patients with MRI confirmed bone erosion vs patients without bone erosion.
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