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Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

Bertalan Mesko1, Szilard Poliska114, Andrea Szegedi3, Zoltan Szekanecz5, Karoly Palatka6, Maria Papp6 and Laszlo Nagy124*

Author Affiliations

1 Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary

2 Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

3 Department of Dermatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

4 Clinical Genomics Center, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

5 Department of Rheumatology, Institute of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary

6 2nd Department of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary

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BMC Medical Genomics 2010, 3:15  doi:10.1186/1755-8794-3-15

Published: 5 May 2010

Additional files

Additional file 1:

List of genes, gene interaction analyses and detailed gene expression data. • Figure S1) List of genes that were measured on the TaqMan Low Density Arrays. • Figure S2) Inclusion and exclusion criteria of diseased patients and healthy controls. • Figure S3) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between IBD and controls. • Figure S4) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between psoriasis and controls. • Figure S5) Gene interaction analysis ("Cell mode" in GeneSpring GX) of the genes differentiating between RA and controls. • Figure S6) Number of diseased patients with gene expression levels outside the range of the mean ± SD or 2 SD in control sample. Based on Figure 6. • Figure S7) Stratifying IBD: The results of the RT-QPCR measurements for each gene that showed significant differences between Crohn's disease vs Ulcerative colitis patients. • Figure S8) Stratifying Psoriasis: The results of the RT-QPCR measurements for each gene that showed significant differences between arthritis negative vs positive forms. • Figure S9) Stratifying RA: The results of the RT-QPCR measurements for each gene that showed significant differences between patients with MRI confirmed bone erosion vs patients without bone erosion.

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