Additional file 8.
Scatter plot of the Connectivity MAP (CMAP) connectivity score vs. the connectivity score-based rank as provided by the CMAP algorithm. The gene set correlated with PER1 was queried against ~6000 different treatments, comprised of various treatments and doses in the CMAP database The green curve represents treatments with positive scores (resulting in overall downregulation after treatment); the red curve represents treatments with negative scores (resulting in overall upregulation after treatment), and the gray portion of the curve represents inconsistent or insignificant direction of change post-dose. Sirolimus treatments with various concentrations are indicated by white markers.
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Loboda et al. BMC Medical Genomics 2009 2:7 doi:10.1186/1755-8794-2-7