Schematic of study design. The first biopsy procedure was performed at 6:30 am to 8:30 am, followed by two more biopsies: one in the afternoon (12:30 pm to 2:30 pm) and one in the evening (4:30 pm to 6:30 pm). The same subject in this crossover design received 9 biopsies over the study duration, with at least 7 days in between visits. In total, 153 adipose samples were obtained and hybridized (17 subjects × 3 time points × 3 periods).
Loboda et al. BMC Medical Genomics 2009 2:7 doi:10.1186/1755-8794-2-7