Open Access Research article

Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity

Béatrice Regnault1, José Osorio y Fortea2, Dongmei Miao3, George Eisenbarth3 and Evie Melanitou2*

Author Affiliations

1 Institut Pasteur, 1 Genopole, Department of Genetics & Genomics 25-28 rue du Dr Roux, 75015 Paris, France

2 Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 25-28 rue du Dr Roux, 75015 Paris, France

3 Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80010, USA

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BMC Medical Genomics 2009, 2:63  doi:10.1186/1755-8794-2-63

Published: 2 October 2009

Additional files

Additional file 1:

Sequences corresponding to probes used as primers for amplification of selected genes by Real Time Q-RT-PCR.

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Additional file 2:

Quality evaluation of the arrays by box plots metrics. RMA-normalized data distribution for the E-IAA positive and the E-IAA negative groups

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Additional file 3:

Genes differentially expressed in the PLN of 5 weeks old NOD mice according to E-IAA sub-phenotype and adjusted P-values.

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Additional file 4:

Genes specifically expressed in the pancreas but not found to be expressed in the E-IAA PLN transcriptome.

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Additional file 5:

Functional categories of genes and ESTs as annotated by GO and PANTHER tools. Molecular functions and Biological process terms are as described in the text for Table 2.

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Additional file 6:

Assignment of functional categories as annotated by literature data mining, for genes and ESTs differentially expressed in the PLN of E-IAA NOD sub-phenotype, as described in the text (Table 3). References, corresponding to bibliographic search for functions for each gene, are given.

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