(a) A significant Diagnosis × Glucose deprivation × Probeset interaction effect on GLS expression was detected by exon array. Exon array probeset expression levels are shown for the entire transcript. The probe set number is shown on the x-axis and the average expression for each diagnosis group is depicted on the y-axis. There was a significant decrease in probeset expression in subjects with schizophrenia (shown in blue) compared to controls (shown in red), under normal glucose conditions (b) The probeset with the most significant Diagnosis × Glucose interaction was probeset 2520346 (p = 0.001). Posthoc analysis revealed a significant decrease in GLS probeset expression in subjects with schizophrenia before and after glucose deprivation compared to normal controls (p = 0.001 and 0.0002, respectively).
Martin et al. BMC Medical Genomics 2009 2:62 doi:10.1186/1755-8794-2-62