Table 3

Functional profiling of differentially expressed genes in GK compared to BN rats in adipose tissue (n = 1075) and liver (n = 233) using GENECODIS.

KEGG pathway(s)

Number of genes

Corrected p-value


Adipose tissue

Prostaglandin and leukotriene metabolism

10

0.001

Focal adhesion | ECM-receptor interaction | Hematopoietic cell lineage | Regulation of actin cytoskeleton

4

0.002

ECM-receptor interaction | Hematopoietic cell lineage

5

0.002

ECM-receptor interaction

11

0.002

Glycolysis/Gluconeogenesis

9

0.003

Focal adhesion | ECM-receptor interaction

9

0.003

Arginine and proline metabolism

8

0.005

Glycolysis/Gluconeogenesis | Fructose and mannose metabolism

4

0.005

Glycolysis/Gluconeogenesis | Pentose phosphate pathway | Fructose and mannose metabolism

3

0.012

Hematopoietic cell lineage

9

0.015

Cell Communication | Focal adhesion | ECM-receptor interaction

6

0.019

Fructose and mannose metabolism

6

0.019

Porphyrin and chlorophyll metabolism

5

0.029

Folate biosynthesis

5

0.031

Metabolism of xenobiotics by cytochrome P450

7

0.033

Cytokine-cytokine receptor interaction | Focal adhesion

3

0.033

Focal adhesion

14

0.033

Valine, leucine and isoleucine degradation

6

0.033

Cholera – Infection

5

0.033

Fructose and mannose metabolism | Galactose metabolism

3

0.033

Urea cycle and metabolism of amino groups

4

0.033

Glycine, serine and threonine metabolism

5

0.044


Liver

Arginine and proline metabolism

7

2.17E-06

Alanine and aspartate metabolism | Arginine and proline metabolism

3

2.09E-05

Alanine and aspartate metabolism

4

1.30E-04

Urea cycle and metabolism of amino groups | Arginine and proline metabolism

3

0.0017

Prostaglandin and leukotriene metabolism

4

0.0019

Valine, leucine and isoleucine degradation | Butanoate metabolism

3

0.0030

Fatty acid metabolism

3

0.0103

ECM-receptor interaction

3

0.0361


Herrera et al. BMC Medical Genomics 2009 2:54   doi:10.1186/1755-8794-2-54

Open Data