Table 2

MiRNA microarray analysis reveals differential expression between hyperglycaemic and normoglycaemic rats

Rank

miRNA

Fold change

(GK vs. BN)

P-value

Adjusted

P-value


Liver

1

miR-125a

5.61

0.001

0.104

2

miR-30e

1.56

0.009

0.522

3

miR-210

1.56

0.013

0.522

4

miR-221

1.60

0.015

0.522

5

miR-223

1.50

0.015

0.522

6

miR-365

1.41

0.029

0.592

7

miR-26b

1.51

0.031

0.592

8

miR-23a

2.30

0.032

0.592

9

miR-222

1.38

0.033

0.592

10

miR-29c

1.52

0.038

0.592

11

miR-30a-3p

1.32

0.045

0.592

12

miR-22

-1.39

0.050

0.592


Adipose tissue

1

miR-322

1.91

0.029

0.999

2

let-7c

-2.27

0.040

0.999

3

let-7b

-2.17

0.046

0.999

4

miR-29a

1.51

0.049

0.999

5*

miR-125a

1.97

0.078

0.999


Differences in miRNA expression levels in 4 hyperglycaemic GK rats compared to 4 normoglycaemic BN rats in liver and adipose tissue. For each tissue, one GK and one BN sample were hybridized to each array in a two-colour experiment (4 arrays per tissue). M-ratios therefore represent the log2 intensity ratio in the two strains. The limma package from BioConductor was used to find miRNAs differentially expressed between GK and BN rats and the top ranking genes for each tissue are shown. * miR-125a is shown in this table to illustrate the potential overlap of signals detected in liver and adipose tissue.

Herrera et al. BMC Medical Genomics 2009 2:54   doi:10.1186/1755-8794-2-54

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