Open Access Highly Accessed Research article

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

Blanca M Herrera12, Helen E Lockstone1, Jennifer M Taylor1, Quin F Wills3, Pamela J Kaisaki1, Amy Barrett2, Carme Camps1, Christina Fernandez1, Jiannis Ragoussis1, Dominique Gauguier14, Mark I McCarthy12 and Cecilia M Lindgren12*

Author Affiliations

1 Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK

2 Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Headington, Oxford, OX3 7LJ, UK

3 Department of Statistics, 1 South Parks Road, Oxford, OX1 3TG, UK

4 INSERM U872, Centre de Recherche des Cordeliers, Rue de l'Ecole de Medecine, 75006 Paris, France

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BMC Medical Genomics 2009, 2:54  doi:10.1186/1755-8794-2-54

Published: 18 August 2009

Additional files

Additional file 1:

Outline of methodology for analysis and integration of miRNA and mRNA expression data from hyperglycaemic GK and normoglycaemic BN rats.

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Additional file 2:

Results of intra-peritoneal glucose tolerance test (IPGTT) measurements carried out at four-months of age on animals representative of the colony GK = 8 BN = 4 *P < 0.05, **P < 0.01, ***P < 0.001 significance.

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Additional file 3:

Overlap of target-gene lists predicted for miRNA rno-miR-125a using three algorithms.

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Additional file 4:

Tissue differences in miRNA expression (liver vs. fat)

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Additional file 5:

Functional profiling and gene-symbols of differentially expressed genes in GK compared to BN rats in adipose tissue (n = 1075) and liver (n = 233) using GENECODIS

Format: XLS Size: 36KB Download file

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Additional file 6:

In-Silico functional profiling of miR-125a targets predicted by miRanda (worksheet 1), TargetScan (worksheet 2), and PicTar (worksheet 3).

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