Table 2

Canonical pathways significant in the transition from normal prostate to localized prostate cancer (functional annotation by Ingenuity)*

Pathway

-Log (P)


Calcium signaling

4.62

NRF2-mediated oxidative stress response

4.05

Actin cytoskeleton signaling

3.31

Tight junction signaling

3.19

Synaptic long term potentiation

3.05

Hepatic fibrosis/hepatic stellate cell activation

2.99

Integrin signaling

2.58

EGF signaling

2.45

GM-CSF signaling

2.38

Regulation of actin-based motility by Rho

2.12

Wnt/beta-catenin signaling

2.04

PDGF signaling

2.04

Xenobiotic metabolism signaling

1.98

Chemokine signaling

1.94

Arginine and proline metabolism

1.94

Cell cycle: G1/S checkpoint regulation

1.86

ERK/MAPK signaling

1.79

cAMP-mediated signaling

1.77

VEGF signaling

1.65

Leukocyte extravasation signaling

1.61

Neuregulin signaling

1.60

Nitric oxide signaling in the cardiovascular system

1.54

Glutathione metabolism

1.54

LPS/IL-1 mediated inhibition of RXR function

1.52

Purine metabolism

1.41

Fatty acid biosynthesis

1.34

Aryl hydrocarbon receptor signaling

1.34

Glucocorticoid receptor signaling

1.34


*Lists of the significant genes in each pathway are shown in Additional file 5.

Gorlov et al. BMC Medical Genomics 2009 2:48   doi:10.1186/1755-8794-2-48

Open Data