Table 4

Oncogenes and tumor suppressor genes known to be associated with genomic changes in lung adenocarcinoma

Gene

CNA class

Cytoband

Deletion (%)

Amplification (%)


FHIT

k = 3 (D)

3p14.2

52.3

1.5


LIMD1

k = 3 (D)

3p21.3

34.4

1.5


hTERT

k = 7 (A)

5p15.33

6.2

55.4


SKP2

k = 7 (A)

5p13

1.5

38.5


EGFR-1

k = 7 (A)

7p11.2

1.5

24.6


c-MET

k = 7 (A)

7q31

7.7

23.1


c-MYC

k = 7 (A)

8q24.12-13

4.6

36.9


CDKN2A

k = 3 (D)

9p21

29.2

6.2


PTEN

k = 2 (D)

10q23.3

18.5

5.2


CCND1

k = 7 (A)

11q13

6.2

21.5


RB

k = 3 (D)

13q14.2

43.1

1.5


NKX2-1

k = 7 (A)

14q13.3

3.1

21.5


WWOX

k = 3 (D)

16q23.3-24.1

33.8

6.2


P53

k = 3 (D)

17p13.1

36.9

4.6


E2F

k = 7 (A)

20q11.2

3.1

23.1


Bro√ęt et al. BMC Medical Genomics 2009 2:43   doi:10.1186/1755-8794-2-43

Open Data