Table 1

Genes differentially expressed between diabetic models and controls that map to regions conserved with human DN susceptibility loci.

GK vs WKY

STZ vs WKY

STZ vs GK

Gene Symbol

Gene description

Genbank

TR

p-value

TR

p-value

TR

p-value


Human 3q23-q29

Bdh

3-hydroxybutyrate dehydrogenase

NM_053995

+1.3

Ns

-1.2

Ns

-1.6

0.007

Centb2

Centaurin beta 2

BM389190

-1.4

Ns

1.0

Ns

+1.3

0.047

Clcn2

Chloride channel 2

NM_017137

+1.2

Ns

-1.1

Ns

-1.4

0.038

Cldn16

Claudin 16

NM_131905

-1.1

Ns

-1.6

0.002

-1.4

0.01

Dgkg

Diacylglycerol kinase gamma

NM_013126

+1.2

Ns

+1.6

0.025

+1.3

Ns

Dnajb11

DnaJ (Hsp40) subfamily B11

BI295873

1.0

Ns

-1.3

0.043

-1.3

Ns

Eif4g1

Eukaryotic translation initiation factor

BC098868

+1.1

Ns

-1.2

Ns

-1.4

0.011

Fad104

FAD104 (predicted)

AI176320

+1.3

Ns

-1.3

0.05

-1.7

5 × 10-4

Fam43a

Family with sequence similarity 43A

BE108405

-1.1

Ns

-1.7

0.017

-1.5

Ns

Hrg

Histidine-rich glycoprotein

NM_133428

-1.2

Ns

+2.0

0.034

+2.5

0.007

Mfn1

Mitofusin 1

AI169627

1.0

Ns

+1.7

0.046

+1.7

0.035

AA943135

1.0

Ns

+1.5

0.018

+1.5

0.009

Ncbp2

Nuclear cap binding protein subunit 2

BI282103

+1.3

Ns

-1.5

0.046

-2

0.002

Pld1

Phospholipase D1

U69550

-1.3

Ns

-1.8

0.036

-1.4

Ns

Pigx

Subunit of GPI-mannosyltransferase

AI172192

+1.3

Ns

1.0

Ns

-1.3

0.043

Rbp1

Retinol binding protein 1

NM_012733

1.0

Ns

+2.3

3 × 10-4

+2.2

3 × 10-4

Siat1

Sialyltransferase 1

M83143

1.0

Ns

-1.6

0.002

-1.6

0.001

Slc2a2

Solute carrier family 2 member 2 (Glut2)

NM_012879

+3.0

5 × 10-4

+3.6

1 × 10-4

+1.2

Ns

Ssr3

Signal sequence receptor gamma

NM_031120

-1.2

Ns

+1.3

Ns

+1.6

0.003

Zbed4

Zinc finger, BED domain containing 4

AI170289

-1.1

Ns

-1.3

0.046

-1.2

Ns

---

Similar to protein NP_079596

AI412011

+1.4

Ns

-1.5

0.044

-2.1

0.001

Human 7q32.3-q33

Akr1b4

Aldo-keto reductase family 1B4

NM_012498

1.0

Ns

+2.2

Ns

+2.1

0.024

Akr1b8

Aldo-keto reductase family 1B8

NM_173136

-6.2

6 × 10-5

+1.4

Ns

+8.5

8 × 10-6

Slc35b4

Solute carrier family 35 member B4

XM_216122

+1.2

Ns

-1.1

Ns

-1.4

0.010

Human 18q12-q23

Acaa2

Acetyl-Coenzyme A acyltransferase 2

NM_130433

-1.6

0.041

-1.3

Ns

+1.2

Ns

Brunol4

RNA binding protein bruno-like 4

AW530502

+1.1

Ns

+1.3

0.036

+1.2

Ns

Cndp1

Carnosinase 1

AI231438

1.0

Ns

-3.4

3 × 10-5

-3.5

8 × 10-6

Cndp2

Carnosinase 2

BI279729

+1.1

Ns

-1.3

0.042

-1.4

0.01

G0S2

Putative lymphocyte G0/G1 switch gene

AI406939

+1.3

Ns

-1.6

Ns

-2.1

0.004

Mapk4

Mitogen-activated protein kinase 4

BG378232

+1.3

Ns

+1.5

0.023

+1.2

Ns

Mep1b

meprin 1 beta (endopeptidase-2)

NM_013183

1.0

Ns

-1.4

0.042

-1.4

0.050

Pqlc1

PQ loop repeat containing 1

AI228284

+1.6

0.044

+1.7

0.011

+1.1

Ns

Slc14a2

Solute carrier family 14, member 2

NM_019347

-1.1

Ns

+1.5

0.020

+1.7

0.005

AF042167

-1.1

Ns

+1.4

Ns

+1.6

0.035

Human 20p12.3-p13

Cdc25b

Cell division cycle 25 homolog B

NM_133572

+1.2

Ns

+1.6

0.028

+1.4

Ns

Prnp

Prion protein

NM_012631

+1.6

0.029

+1.1

Ns

-1.5

0.030


Gene expression results from Affymetrix chip hybridizations are given as transcription ratio (TR). The list of genes in these regions represented on the Affymetrix chip and not differentially expressed is given in Additional file 7. Ns, not statistically significant differences.

Hu et al. BMC Medical Genomics 2009 2:41   doi:10.1186/1755-8794-2-41

Open Data