Open Access Research article

NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines

Tineke E Buffart, Marianne Tijssen, Jamila El-Bchiri, Alex Duval, Mark A van de Wiel, Bauke Ylstra, Gerrit A Meijer and Beatriz Carvalho*

BMC Medical Genomics 2009, 2:39  doi:10.1186/1755-8794-2-39

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PTPRJ mutation

Rodolfo Iuliano   (2009-07-08 11:10)  Università di Catanzaro email

Buffart et al. in this paper affirm that they found a mutation (Glu836Asp) in PTPRJ gene. They reported the sequence of the region surrounding the mutation and, indeed, the sequence perfectly matches with that of exon 13 that includes a well known polymorphism of PTPRJ (Asp872Glu, SNP ID rs 4752904). Thus, also in this case, as correctly reported for the other two polymorphisms of PTPRJ, the authors detected a polymorphism and not a mutation of PTPRJ.

Competing interests

None declared


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