Resensitization of cisplatin-resistant Round5 A2780 cells by 5-aza-dC and zebularine. A) Growth curves for cisplatin in the presence of 5-aza-dC pretreatment. In the absence of cisplatin, higher 5-aza-dC dosage achieves higher cell death. The same dosage of cisplatin achieves higher cell death with higher dosages of 5-aza-dC, demonstrating increased cisplatin sensitivity by 5-aza-dC. B) The same resensitization experiment was performed for zebularine, using higher dosages (0–200 μM) [49,50]. C) The cisplatin GI50 values measured by MTT assay showed a dose-dependent decrease by 5-aza-dC. D) The cisplatin GI50 values measured by MTT assay showed a dose-dependent decrease by zebularine.
Li et al. BMC Medical Genomics 2009 2:34 doi:10.1186/1755-8794-2-34