Open Access Highly Accessed Research article

Detailed transcriptome atlas of the pancreatic beta cell

Burak Kutlu1*, David Burdick1, David Baxter1, Joanne Rasschaert2, Daisy Flamez2, Decio L Eizirik2, Nils Welsh3, Nathan Goodman1 and Leroy Hood1

Author Affiliations

1 Institute for Systems Biology, Seattle, WA, USA

2 Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium

3 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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BMC Medical Genomics 2009, 2:3  doi:10.1186/1755-8794-2-3

Published: 15 January 2009

Additional files

Additional file 1:

Supplementary methods. Supplementary information about Methods and additional findings.

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Additional file 2:

MPSS gene expression data. Tpm values for each gene in MPSS data.

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Additional file 3:

GO term enrichment analysis of MPSS data. GO term enrichment analysis of 1: top 200 genes, 2: genes expressed lower than 25 transcripts per million (tpm) in the human islet MPSS data

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Additional file 4:

Transcription factor analysis. Analysis of transcription factors in rat INS cell data based on domain classification.

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Additional file 5:

INS-1 cell microarray data analysis results. This file contains 1. MAS5-normalized expression data of rat β, α and INS cell. 2. Differential expression analysis of genes expressed in β vs α cells. 3. Differential expression analysis of genes expressed in β vs INS cells.

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Additional file 6:

GO term enrichment analysis of INS cell data. GO term enrichment analysis genes expressed in β, α and INS cells.

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Additional file 7:

Pancreatic islet-specific genes. Genes that are enriched in pancreatic islets compared to other tissues in the body.

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Additional file 8:

The overlap of these pancreatic islet-specific genes with β and α cell enriched genes. The intersection of genes in Additional File 7 with either genes expressed strongly in either β or α cells.

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