Table 1

Functional profiling, positively correlated genes

Functional group

Gene set name

No. of related sets

No of members in gene set

(range)

FDR q value

(range)


Vesicle trafficking

Membrane fusion

2

27–52

0.022–0.026

Vesicle transport

9

16–348

0.002–0.149

Vesicle docking during exocytosis

1

21

0.141


Transcription/translation

Ribosome function

4

69–89

0.042–0.179

mRNA processing

5

157–452

0.056–0.166

Transcription from RNA pol III promoter

1

25

0.089

mRNA catabolism

2

17–23

0.027–0.125

translation

3

30–157

0.012–0.062


Protein transport/metabolism

Protein transport

9

17–294

0.012–0.129

Ubiquination/proteolysis

11

133–448

0.013–0.024

Protein folding

1

195

0.003

Carboxylic acid metabolism

7

17–410

0.087–0.195

Aspartate family amino acid metabolism

1

18

0.016

Amine metabolism

2

55–57

0.142–0.152


Electron transport chain

Coenzyme metabolism

4

85–159

0.007–0.029

Nucleotide metabolism

16

53–178

0.014–0.126

ATP metabolism

9

36–490

0.012–0.192

Oxidative phosphorylation

4

21–63

<0.001

Electron transport

1

289

0.022

Mitochondrial membrane

2

19–21

0.027–0.149


Glycolysis

Aerobic respiration

7

22–32

0.005–0.016

Glucose metabolism

13

20–138

0.005–0.079


Oxidative stress

Response to oxidative stress

2

44–63

0.069–0.164

Peroxisome organization and biogenesis

1

17

0.164


Cell cycle

Mitotic cell cycle

5

17–60

0.077–0.144

Induction of apoptosis by intracellular signals

1

20

0.067


Lipid metabolism

Sphingomyelin synthesis

3

17–41

0.035–0.187

Lipid modification

2

15–19

0.032–0.041

Phospholipid metabolism

6

54–427

0.012–0.054

Lipoprotein metabolism

3

29–42

0.027–0.069

Glycerolipid metabolism

6

19–39

0.013–0.180


Others

Iron compound metabolism

6

15–52

0.002–0.053

Autophagy

1

16

0.062

Polysaccharide biosynthesis

1

18

0.120

Biopolymer biosynthesis

1

18

0.128

Telomere maintenance

1

21

0.132

Respiratory gaseous exchange

1

17

0.188

Regulation of Wnt receptor signalling

1

15

0.188

Vitamin metabolism

1

48

0.188


Functional gene sets are shown which show enrichment in the list of genes positively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.

Harris et al. BMC Medical Genomics 2009 2:28   doi:10.1186/1755-8794-2-28

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