Network diagrams for HIV1, host protein interactions. (A) The scheme for identifying HHP. Rectangular blocks represent ELMs and ellipses represent their CDs. (B) An HIV-1 protein (yellow) alters the human PPI network by creating a new path between proteins (blue). (C) An HIV-1 protein breaks a path between two human proteins (blue) by competing for binding [3-5]. (D) Interactions between HIV-1 and human proteins, as predicted by HHP and HHE using HPRD. Nodes are proteins and edges represent a protein-protein interaction. Yellow nodes represent HIV-1 proteins. Purple nodes represent the overlap between HHP and HHE. Blue and red nodes represent proteins specific to HHP and HHE, respectively, while green nodes are not involved in infection.
Evans et al. BMC Medical Genomics 2009 2:27 doi:10.1186/1755-8794-2-27