Overview of the microarray data integration. A)"DNA/RNA outlier plot" of cell line ZR-75-1. The x-axis indicates the DNA copy number ratio of all 54675 probe sets on the Affymetrix U133plus2.0 array. These ratios were calculated from Agilent array CGH data for the same genes. The y-axis indicates the expression ratio of all probe sets compared to the median of other cell lines. Putative NMD hits are shown in red. RIC8A is both heterozygously deleted, underexpressed compared to the other cell lines and its expression was induced by emetine treatment. B)A schematic view of chromosome 11 in ZR-75-1, as well as the deleted region at 11p15.5. RIC8A is located ~200 kb from the p-telomere.
Muggerud et al. BMC Medical Genomics 2009 2:26 doi:10.1186/1755-8794-2-26