Research article
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data
-
* Corresponding author: Roger W Beuerman rwbeuer@mac.com
1 Singapore Eye Research Institute (SERI), Singapore National Eye Center, Singapore
2 Transcriptomics Platform, Singapore Immunology Network, Singapore
3 Department of Cornea and External eye disease, Singapore National Eye Center, Singapore
4 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
BMC Medical Genomics 2009, 2:14 doi:10.1186/1755-8794-2-14
Published: 10 March 2009Additional files
Additional File 1:
Clinical appearance of pterygium on color photographs. A. Primary pterygium and B. Recurrent pterygium. Note the excessive scarring that is typical of recurrent pterygium.
Format: DOC Size: 26KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional File 2:
Primary and recurrent pterygium specific genes. Heat map showing pterygium specific and recurrence specific genes. Note that in recurrent pterygium a larger number of genes were relatively down-regulated (green) compared to primary pterygium and un-involved conjunctiva, and a smaller but still large number of genes were up-regulated (red) compared to primary pterygium and un-involved conjunctiva.
Format: DOC Size: 83KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional File 3:
Postulated pterygium recurrence pathways. These pathways A and B were obtained from pathway analysis. Red symbols: genes up-regulated in recurrent pterygia compared to primary pterygia.
Format: DOC Size: 94KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional File 4:
Immunofluorescence image showing staining for CD24 in the pterygium epithelium.
Format: TIFF Size: 1.8MB Download file
Additional File 5:
Relationships in the pathway studio 5.0 analysis for up-regulated genes.
Format: TIFF Size: 249KB Download file
Additional File 6:
Relationships in the pathway studio 5.0 analysis for down-regulated genes.
Format: TIFF Size: 312KB Download file