Table 3

List of genes selected from microarrays analysis comparing normal mucosa matched tumour colon tissue. The different expression in tumoural tissue was showed.

Function/category

Gene

Accession no.

Microarray Data

Gene description

P value

Expression


Insulin Receptor Signaling

SGK1

NM_005627.1

0.059

down

Serum glucocorticoid regulated kinase (SGK)

Transport

CLCA4

NM_012128.2

0.052

down

chloride channel, calcium activated, family member 4

Transport

SLC26A3/DRA

NM_000111.1

0.044

down

solute carrier family 26, member 3 (SLC26A3)

Transport

AQP8

NM_001169.1

0.052

down

aquaporin 8

Transport

SCNN1B

NM_000336.1

0.046

down

sodium channel, nonvoltage-gated 1, beta (S. Liddle)

Transport (ATP binding)

ABCA8

NM_007168.1

0.040

down

ATP-binding cassette, sub-family A (ABC1), member 8

Protein transport

STX12

AI816243

0.051

down

syntaxin 12

Receptor activity (mineralcorticoid)

NR3C2

NM_000901.1

0.049

down

nuclear receptor subfamily 3, group C, member 2

Cell cycle (proliferation)

MXI1

NM_005962.1

0.053

down

MAX-interacting protein 1 (MXI1)

Cell cycle (differentiation)

NDRG2

NM_016250.1

0.039

down

N-myc downstream-regulated gene 2

Prostaglandin metabolism

HPGD

J05594.1

0.050

down

hydroxyprostaglandin dehydrogenase 15-(NAD)

Prostaglandin and leukotriene Metabolism

PRDX6

NM_004905.1

0.050

down

peroxidase, acidic calcium-independent phospholipase A2

Signal tansduction

SGK2

NM_016276.3

0.038

down

serumglucocorticoid regulated kinase (SGK)

Transcription factors

FOXM1

NM_021953.1

0.046

up

forkhead box M1 (FOXM1)

Transcription factors

GTF2IRD1

NM_016328.1

0.046

up

GTF2I repeat domain-containing 1 (GTF2IRD1)

Transcription factor

SOX9

NM_000346.1

0.045

up

Sex determining region Y-box 9

ATP-binding/proteins folding

HSPH1

BG403660

0.043

up

heat shock 105 kD (HSP105B)

Transport solute carrier

SLC12A2

NM_001046

0.048

up

solute carrier family 12

Cell cycle (proliferation)

TPX2

NM_012112.1

0.044

up

restricted expressed proliferation associated protein

Cell cycle (progression)

UBE2C

NM_007019.1

0.050

up

ubiquitin carrier protein E2-C (UBCH10)

Cell cycle (proliferation)

CSE1L/CAS

NM_001316

0.052

up

CSE1 chromosome segregation 1-like (yeast)

Signal Transduction

CCNB1

Hs.23960

0.048

up

cyclin B1

Focal adhesion

NEBL

NM_006393.1

0.038

up

nebulette protein (NEBL, actin-binding Z-disc protein)

Replication and repair

RFC3

BC000149

0.049

up

replication factor C (activator 1) 3 (38 kD)


Piepoli et al. BMC Medical Genomics 2009 2:11   doi:10.1186/1755-8794-2-11

Open Data