Table 6 |
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|
Pterostilbene-responsive genes involved in sulfur metabolism and/or assimilation |
||||
|
Accession |
Gene |
Ratio |
p-value |
Gene Description |
|
|
||||
|
a. Methionine metabolism |
||||
|
YJR137C |
ECM17 |
-2.5 |
2.48 × 10-5 |
Sulfite reductase beta subunit |
|
YKR069W |
MET1 |
-3.1 |
3.88 × 10-4 |
AdoMet-dependent uroporphyrinogen III transmethylase |
|
YJR010W |
MET3 |
-3.8 |
3.5 × 10-4 |
ATP sulfurylase |
|
YER091C |
MET6 |
-2.4 |
8.83 × 10-5 |
Cobalamin-independent methionine synthase |
|
YFR030W |
MET10 |
-2.1 |
1.5 × 10-3 |
Sulfite reductase alpha subunit |
|
YGL125W |
MET13 |
-3.6 |
1.46 × 10-4 |
Methylenetetrahydrofolate reductase |
|
YKL001C |
MET14 |
-3.1 |
1.12 × 10-3 |
Adenylylsulfate kinase |
|
YPR167C |
MET16 |
-2.0 |
7.56 × 10-4 |
3'-phosphoadenylylsulfate reductase |
|
YOL064C |
MET22 |
-2.5 |
1.68 × 10-4 |
Bisphosphate-3'-nucleotidase, |
|
YLL062C |
MHT1 |
-3.4 |
6.69 × 10-4 |
S-methylmethionine-homocysteine methyltransferase |
|
YLR180W |
SAM1 |
-2.1 |
6.39 × 10-5 |
S-adenosylmethionine synthetase |
|
b. Sulfur and aspartate family amino acid metabolic processes (in addition to a) |
||||
|
YNL103W |
MET4 |
3.0 |
4.01 × 10-4 |
Leucine zipper transcriptional activator |
|
YPL038W |
MET31 |
2.2 |
2.45 × 10-3 |
Transcriptional regulator highly homologous to Met32p |
|
YJR130C |
STR2 |
2.3 |
2.97 × 10-3 |
Cystathionine gamma-synthase |
|
YGL184C |
STR3 |
-3.6 |
4.1 × 10-3 |
Cystathionine beta-lyase |
|
YJR060W |
CBF1 |
-3.0 |
1.11 × 10-3 |
Basic helix-loop-helix protein |
|
YHR025W |
THR1 |
-2.2 |
2.05 × 10-4 |
Homoserine kinase |
|
c. All other genes affected under the term "sulfur metabolism" |
||||
|
YLL060C |
GTT2 |
2.5 |
8.23 × 10-4 |
Glutathione transferase |
|
YEL017W |
GTT3 |
-2.2 |
6.72 × 10-4 |
Protein with a possible role in glutathione metabolism |
|
YGR286C |
BIO2 |
-3.0 |
9.79 × 10-4 |
Biotin synthase |
|
YJL212C |
OPT1 |
-2.5 |
1.8 × 10-4 |
Peptide transporter/glutathione transporter |
|
YLL057C |
JLP1 |
13.5 |
6.93 × 10-4 |
Fe(II)-dependent sulfonate/α-ketoglutarate dioxygenase |
|
YLR043C |
TRX1 |
-2.1 |
6.95 × 10-5 |
Cytoplasmic thioredoxin |
|
d. Sulfur uptake |
||||
|
YBR294W |
SUL1 |
-5.53 |
4.64 × 10-5 |
Sulfate uptake (transporter) |
|
YLR092W |
SUL2 |
-2.75 |
1.89 × 10-4 |
High affinity sulfate permease |
|
|
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|
Pan et al. BMC Medical Genomics 2008 1:7 doi:10.1186/1755-8794-1-7 |
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