Research article
Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients
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* Corresponding author: Salla Ruosaari salla.ruosaari@helsinki.fi
- † Equal contributors
1 Biological Mechanisms and Prevention of Work-related Diseases, Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI-00250 Helsinki, Finland
2 Department of Information and Computer Science, Helsinki University of Technology, Konemiehentie, Espoo, Finland
3 Unit of Excellence for Immunotoxicology, Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu, Helsinki, Finland
4 Department of Pathology, Haartman Institute, University of Helsinki, and HUSLAB, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
5 Department of Molecular Medicine, National Public Health Institute, Mannerheimintie, Helsinki, Finland
6 Biomedicum Bioinformatics Unit, Biomedicum, Haartmaninkatu, Helsinki, Finland
7 Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse, Hamburg, Germany
BMC Medical Genomics 2008, 1:55 doi:10.1186/1755-8794-1-55
Published: 11 November 2008Additional files
Additional file 1:
Up-regulated pathways in the normal (N) and tumour (T) tissue identified using the t-test and fold change (fc). The results are presented for the terms for which at least one of the four tests gives p < 0.001 (shown in italics). P-values > 0.2 are given as na.
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Additional file 2:
Down-regulated pathways in the normal (N) and tumour (T) tissue identified using the t-test and fold change (fc). The results are presented for the terms for which at least one of the four tests gives p < 0.001 (shown in italics). P-values > 0.2 are given as na.
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Additional file 3:
Pathways that were differentially regulated both in the normal and tumour tissue of asbestos-exposed patients compared to non-exposed patients. Only the most specific GO terms are presented as the terms share a parent-child relationship where children are detailed descriptions of the parents. The presented GO terms were found to be differentially expressed using both t-test and fold change based ranking with permuted p-value < 0.05.
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