BMC Medical Genomics

official impact factor 3.77

Open Access Highly Access Research article

Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

Yohan Lee1, Adrienne C Scheck2, Timothy F Cloughesy3,6, Albert Lai3, Jun Dong5, Haumith K Farooqi, Linda M Liau4,6, Steve Horvath5, Paul S Mischel6 and Stanley F Nelson1,6*

Author Affiliations

1 Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-7088 USA

2 The Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013 USA

3 Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769 USA

4 Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-6901 USA

5 Department of Biostatistics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1772 USA

6 Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California 90095-1781 USA

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BMC Medical Genomics 2008, 1:52 doi:10.1186/1755-8794-1-52

Published: 21 October 2008

Additional files

Additional file 1:

Tumour sample clinical covariates meta-data. e.g. Time of survival (days), sex, and age where available.

Format: XLS Size: 424KB Download file

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Additional file 2:

Standard protocol recommended by Affymetrix used at UCLA DNA Microarray Facility.

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Additional file 3:

List of Affymetrix probesets used for voting each tumour across each of the Affymetrix platforms.

Format: XLS Size: 249KB Download file

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Additional file 4:

The full R code used for Kaplan-Meier survival curves, Multivariate/Univariate Cox proportional Hazards models, and correlations between age and gene expression.

Format: DOC Size: 43KB Download file

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